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Prednisone pred 10 corticosteroid with rheumatoid arthritis. The efficacy of prednisone was examined in the treatment of inflammatory bowel disease. Randomized clinical trials of prednisone to patients with inflammatory bowel disease and Crohn's were conducted. The efficacy of prednisone in short-term treatment Crohn's disease was assessed using the activity index (DAI), and effect of prednisone on disease activity was evaluated using the Crohn disease activity index (CDAI). MECHANISM OF ACTION AND SAFETY Drug Interactions The use of prednisone in combination with other drugs that affect metabolism may increase the clinical risk of prednisone-induced cardiovascular side effects. Interactions with other medications canada pharmacy online coupon may also predispose patients to cardiovascular side effects. Examples of these drug combinations are aspirin, antihypertensive drugs, anticoagulants, corticosteroids, and lithium. Adverse drug interactions with prednisone include cardiovascular adverse effects, as well drug-drug interactions. Cardiovascular drug interactions are described separately below. Antiplatelet agents and beta-blockers, which may diminish the effect of corticosteroid and antipsychotic agents, may also alter the clinical effect of prednisone. Antihypertensive drugs, including β-blockers and sodium-channel blockers, may cause dose-related decreases in total plasma corticosteroid exposure or per hour, resulting in decreased total plasma prednisone exposure and/or corticosteroid per hour. These drug combinations are discussed in further detail below. Chloride-containing diuretics (eg, triamterene, povodone, hydrochlorothiazide) may inhibit the effects of corticosteroids on bone metabolism and mineral density. Anticoagulants are commonly used for treatment of coronary artery disease and may induce thrombotic events, such as myocardial infarction and stroke. Caffeine has been reported to reduce the efficacy of prednisone during first week treatment, and caffeine may induce hyponatremia. Carbohydrates, especially those used as the prime fuel source in digestive tract, have been reported to increase the effects of corticosteroids on kidney and bone metabolism. Patients taking corticosteroids with glucose-containing